A specific chromosome breakpoint associated with mouse plasmacytomas.
J Natl Cancer Inst
; 61(1): 255-8, 1978 Jul.
Article
en En
| MEDLINE
| ID: mdl-276632
ABSTRACT
The chromosomes of uncultured cells of the near-diploid mouse plasmacytoma MOPC-31C were studied. The modal number of chromosomes was 44. The tumor lacked two marker chromosomes, reciprocal translocation [rcp t(12; 15)], that in previous studies were found to be common to 3 other uncultured myelomas and 1 cultured mouse myeloma. Through the formation of two markers, rcp t(6; 15), unique to this tumor, however, the tumor shared with other tumors and their specific markers a common breakpoint in chromosome "15 at band D3/E. This breakpoint has been found in all mouse plasmacytomas examined with banding thus far and is considered of possible importance in the development of this tumor.
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Banco de datos:
MEDLINE
Asunto principal:
Plasmacitoma
/
Aberraciones Cromosómicas
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Año:
1978
Tipo del documento:
Article