Antiproliferative activity of amino substituted benzo[b]thieno[2,3-b]pyrido[1,2-a]benzimidazoles explored by 2D and 3D cell culture system.

Perin, Natasa; Bobanovic, Kristina; Zlatar, Ivo; Jelic, Dubravko; Kelava, Vanja; Kostrun, Sanja; Markovic, Vesna Gabelica; Brajsa, Karmen; Hranjec, Marijana

Perin, Natasa; Bobanovic, Kristina; Zlatar, Ivo; Jelic, Dubravko; Kelava, Vanja; Kostrun, Sanja; Markovic, Vesna Gabelica; Brajsa, Karmen; Hranjec, Marijana.

Afiliación

Perin N; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, P. O. Box 177, HR-10000 Zagreb, Croatia.
Bobanovic K; Department of General and Inorganic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, P. O. Box 177, HR-10000 Zagreb, Croatia.
Zlatar I; Department of in vitro Pharmacology, Fidelta Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia.
Jelic D; Department of in vitro Pharmacology, Fidelta Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia.
Kelava V; Chemistry Department, Fidelta Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia.
Kostrun S; Chemistry Department, Fidelta Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia.
Markovic VG; Chemistry Department, Fidelta Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia.
Brajsa K; Department of in vitro Pharmacology, Fidelta Ltd., Prilaz baruna Filipovica 29, HR-10000 Zagreb, Croatia. Electronic address: karmen.brajsa@glpg.com.
Hranjec M; Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulicev trg 19, P. O. Box 177, HR-10000 Zagreb, Croatia. Electronic address: mhranjec@fkit.hr.

Eur J Med Chem ; 125: 722-735, 2017 Jan 05.

Article en En | MEDLINE | ID: mdl-27721156

Asunto(s)

Bencimidazoles/farmacología; Bencimidazoles/síntesis química; Bencimidazoles/química; Ácidos Carboxílicos/química; Técnicas de Cultivo de Célula; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Simulación por Computador; Doxorrubicina/química; Doxorrubicina/farmacología; Humanos; Concentración 50 Inhibidora; Estructura Molecular; Análisis Multivariante; Piridonas/química; Relación Estructura-Actividad

Palabras clave

2D and 3D in vitro cytotoxicity assay; Antiproliferative activity; Lipophilicity; Physico-chemical properties; benzo[b]thieno[2,3-b]pyrido[1,2-a]benzimidazoles

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Bencimidazoles Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article

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