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Polyfluorinated salicylic acid derivatives as analogs of known drugs: Synthesis, molecular docking and biological evaluation.
Shchegol'kov, E V; Shchur, I V; Burgart, Ya V; Saloutin, V I; Trefilova, A N; Ljushina, G A; Solodnikov, S Yu; Markova, L N; Maslova, V V; Krasnykh, O P; Borisevich, S S; Khursan, S L.
Afiliación
  • Shchegol'kov EV; Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Science, S. Kovalevskoy Str., 22, Ekaterinburg 620990 Russia. Electronic address: schegolkov@ios.uran.ru.
  • Shchur IV; Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Science, S. Kovalevskoy Str., 22, Ekaterinburg 620990 Russia.
  • Burgart YV; Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Science, S. Kovalevskoy Str., 22, Ekaterinburg 620990 Russia.
  • Saloutin VI; Postovsky Institute of Organic Synthesis of Ural Branch of Russian Academy of Science, S. Kovalevskoy Str., 22, Ekaterinburg 620990 Russia.
  • Trefilova AN; Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm 614990, Russia.
  • Ljushina GA; Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm 614990, Russia.
  • Solodnikov SY; Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm 614990, Russia.
  • Markova LN; Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm 614990, Russia.
  • Maslova VV; Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm 614990, Russia.
  • Krasnykh OP; Perm National Research Polytechnic University, Komsomolsky Av., 29, Perm 614990, Russia.
  • Borisevich SS; Ufa Institute of Chemistry of Russian Academy of Science, Octyabrya Av., 71, Ufa 450078, Russia.
  • Khursan SL; Ufa Institute of Chemistry of Russian Academy of Science, Octyabrya Av., 71, Ufa 450078, Russia.
Bioorg Med Chem ; 25(1): 91-99, 2017 01 01.
Article en En | MEDLINE | ID: mdl-27776888
ABSTRACT
We have developed the convenient methods for synthesis of polyfluorosalicylic acids and their derivatives. For the first time the biological properties of polyfluorosalicylates were investigated in vitro (permeability through the biological membranes, COX-1 inhibitory action) and in vivo (anti-inflammatory, analgesic activities, acute toxicity). Molecular docking of polyfluorinated salicylates confirmed in vitro and in vivo experiments.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Salicilatos / Antiinflamatorios no Esteroideos / Inhibidores de la Ciclooxigenasa / Edema / Analgésicos Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Salicilatos / Antiinflamatorios no Esteroideos / Inhibidores de la Ciclooxigenasa / Edema / Analgésicos Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article