Nitric oxide-donating derivatives of hederacolchiside A1: Synthesis and biological evaluation in vitro and in vivo as potential anticancer agents.
Bioorg Med Chem Lett
; 27(1): 98-101, 2017 01 01.
Article
en En
| MEDLINE
| ID: mdl-27866816
ABSTRACT
A series of nitric oxide (NO) donating derivatives of hederacolchiside A1 bearing triterpenoid saponin motif were designed, synthesized and evaluated for their anticancer activity. All of the tested furoxan-based NO releasing compounds showed significant proliferation inhibitory activities. Especially compound 6a exhibited strong cytotoxicity (IC50=1.6-6.5µM) against four human tumor cell lines (SMMC-7721, NCI-H460, U251, HCT-116) in vitro and the highest level of NO releasing. Furthermore, compound 6a was revealed low acute toxicity to mice and weak haemolytic activity with potent tumor growth inhibition against mice H22 hepatocellular cells in vivo (51.5%).
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Saponinas
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Antineoplásicos
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Óxido Nítrico
Límite:
Animals
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article