siRNA carrying an (E)-vinylphosphonate moiety at the 5Î end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

siRNA carrying an (E)-vinylphosphonate moiety at the 5Î end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Elkayam, Elad; Parmar, Rubina; Brown, Christopher R; Willoughby, Jennifer L; Theile, Christopher S; Manoharan, Muthiah; Joshua-Tor, Leemor.

Afiliación

Elkayam E; Keck Structural Biology Lab, Cold Spring Harbor, NY 11724, USA.
Parmar R; Howard Hughes Medical Institute, Cold Spring Harbor, NY 11724, USA.
Brown CR; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Willoughby JL; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
Theile CS; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
Manoharan M; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.
Joshua-Tor L; Alnylam Pharmaceuticals, 300 Third Street, Cambridge, MA 02142, USA.

Nucleic Acids Res ; 45(8): 5008, 2017 05 05.

Article en En | MEDLINE | ID: mdl-27986853

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2017 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Idioma: En Año: 2017 Tipo del documento: Article