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Rational Design of Novel Highly Potent and Selective Phosphatidylinositol 4-Kinase IIIß (PI4KB) Inhibitors as Broad-Spectrum Antiviral Agents and Tools for Chemical Biology.
Mejdrová, Ivana; Chalupská, Dominika; Placková, Pavla; Müller, Christin; Sála, Michal; Klíma, Martin; Baumlová, Adriana; Hrebabecký, Hubert; Procházková, Eliska; Dejmek, Milan; Strunin, Dmytro; Weber, Jan; Lee, Gary; Matousová, Marika; Mertlíková-Kaiserová, Helena; Ziebuhr, John; Birkus, Gabriel; Boura, Evzen; Nencka, Radim.
Afiliación
  • Mejdrová I; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Chalupská D; Department of Chemistry of Natural Compounds, Institute of Chemical Technology Prague , Technická 5, Prague 166 28, Czech Republic.
  • Placková P; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Müller C; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Sála M; Institute of Medical Virology, Justus Liebig University Giessen , Schubertstrasse 81, D-35392 Giessen, Germany.
  • Klíma M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Baumlová A; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Hrebabecký H; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Procházková E; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Dejmek M; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Strunin D; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Weber J; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Lee G; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Matousová M; Department of Chemistry of Natural Compounds, Institute of Chemical Technology Prague , Technická 5, Prague 166 28, Czech Republic.
  • Mertlíková-Kaiserová H; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Ziebuhr J; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
  • Birkus G; Institute of Medical Virology, Justus Liebig University Giessen , Schubertstrasse 81, D-35392 Giessen, Germany.
  • Boura E; Gilead Sciences, Inc. , 333 Lakeside Drive, Foster City, California 94404, United States.
  • Nencka R; Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Gilead Sciences & IOCB Research Centre , Flemingovo nám. 2, 166 10 Prague 6, Czech Republic.
J Med Chem ; 60(1): 100-118, 2017 01 12.
Article en En | MEDLINE | ID: mdl-28004945
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / 1-Fosfatidilinositol 4-Quinasa / Inhibidores Enzimáticos Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / 1-Fosfatidilinositol 4-Quinasa / Inhibidores Enzimáticos Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article