25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study.
Clin Nutr
; 37(1): 169-176, 2018 02.
Article
en En
| MEDLINE
| ID: mdl-28017448
ABSTRACT
BACKGROUND & AIMS:
A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter resistance (Rint), physician diagnosed asthma ever, wheezing and eczema in a population-based cohort study in 6 year old children.METHODS:
Serum 25(OH) vitamin D concentration was assessed in 3815 children. 25(OH) vitamin D concentrations ≥75 nmol/L were considered as sufficient, between 50 and 75 nmol/L as insufficient, and <50 nmol/L as deficient. FeNO and Rint were measured at the research center. Data on physician diagnosed asthma, wheezing, and eczema were obtained by parent-reported questionnaires.RESULTS:
In comparison with sufficient 25(OH) vitamin D concentration, deficient concentrations were associated with elevated FeNO of ≥25 ppb (OR 2.54; 95% CI 1.34-4.80). In addition, deficient and insufficient 25(OH) vitamin D concentrations were associated with a lower Rint (Z-score -1.26; 95% CI -1.66 to -0.85) (ß -0.75; 95% CI -1.08 to -0.42), and increased risks of eczema (OR 1.65; 95% CI 1.13-2.41) (OR 1.44; 95% CI 1.06-1.95). Insufficient 25(OH) vitamin D concentration were associated with a decreased risk of physician diagnosed asthma ever (OR 0.59; 95% CI 0.38-0.94).CONCLUSIONS:
Our results indicate that lower 25(OH) vitamin D levels are associated with elevated FeNO levels, but lower Rint values. Lower 25(OH) vitamin D levels are also associated with a decreased risk for asthma diagnoses but an increased risk for eczema.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Asma
/
Vitamina D
/
Eccema
Tipo de estudio:
Observational_studies
Límite:
Child
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Female
/
Humans
/
Male
País/Región como asunto:
Europa
Idioma:
En
Año:
2018
Tipo del documento:
Article