Concomitant disseminated histoplasmosis and disseminated tuberculosis after tumor necrosis factor inhibitor treatment: a case report.
BMC Infect Dis
; 17(1): 70, 2017 01 13.
Article
en En
| MEDLINE
| ID: mdl-28086756
ABSTRACT
BACKGROUND:
Tumor necrosis factor antagonist inhibitors have transformed the approach to patients with severe autoimmune conditions, such as rheumatoid arthritis. Although the therapy can be highly effective, TNF-α inhibitors are associated with an increased risk of opportunistic infections. CASE PRESENTATION Here, we report a case of concomitant disseminated histoplasmosis and tuberculosis in a 65-year-old female with rheumatoid arthritis treated with TNF-α inhibitor. Both conditions can be found in disseminated form in immunosuppressed hosts, but co-infection is rare with only a few cases having been reported, to our knowledge, all in HIV patients.CONCLUSIONS:
This case posed a considerable challenge for diagnosis and treatment due to the unusual disseminated co-infection, the overlapping symptoms, and the interactions between medications.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Artritis Reumatoide
/
Tuberculosis
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Infecciones Oportunistas
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Huésped Inmunocomprometido
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Antirreumáticos
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Adalimumab
/
Histoplasmosis
Tipo de estudio:
Etiology_studies
Límite:
Aged
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Female
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Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article