Immune modulation by the hepatitis C virus core protein.
J Viral Hepat
; 24(5): 350-356, 2017 05.
Article
en En
| MEDLINE
| ID: mdl-28092420
ABSTRACT
Hepatitis C virus (HCV) infection is currently the most important cause of chronic viral hepatitis in the world and one of the most frequent indications for liver transplantation. HCV uses different strategies to evade the innate and adaptive immune response, and this evasion plays a key role in determining viral persistence. Several HCV viral proteins have been described as immune modulators. In this review, we will focus on the effect of HCV nucleocapsid core protein in the function of immune cells and its correlation with the findings observed in HCV chronically infected patients. Effects on immune cell function related to both extracellular and intracellular HCV core localization will be considered. This review provides an updated perspective on the mechanisms involved in HCV evasion related to one single HCV protein, which could become a key tool in the development of new antiviral strategies able to control and/or eradicate HCV infection.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas del Núcleo Viral
/
Terapia de Inmunosupresión
/
Hepacivirus
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Interacciones Huésped-Patógeno
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Evasión Inmune
Límite:
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article