Expression and localization of fibroblast growth factor (FGF)23 and Klotho in the spleen: its physiological and functional implications.
Growth Factors
; 34(5-6): 196-202, 2016 12.
Article
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| MEDLINE
| ID: mdl-28095739
ABSTRACT
The FGF23-Klotho signaling axis is known to exert anti-aging effects via calcium-phosphorus metabolism. In mice deficient in FGF23-Klotho signaling, however, the number of splenocytes is reduced. FGF23 is expressed in both bone and spleen, with regulation of its production differing in these organs. As FGF23-Klotho signaling may play an immunological role in the spleen, splenocytes in male C57BL/6J mice were assayed for expression of Klotho or FGF23 by flow cytometry and immunohistochemistry. Cells that expressed Klotho included CD45R/B220+ CD21/CD35+ CD1d+ CD43- marginal zone B cells. These cells also expressed FGF receptor 1, indicating that Klotho-positive B cells could respond to FGF23. Plasmacytoid dendritic cells (pDCs) with CD11c+ CD45R/B220+ CD11b- CD8α- were found to produce FGF23. Klotho-positive cells and FGF23-producing cells were present in close proximity to each other, suggesting that FGF23 produced by pDCs may act within a limited area. These findings indicate that FGF23-Klotho signaling could play a biological or immunological role in the spleen.
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MEDLINE
Asunto principal:
Bazo
/
Factores de Crecimiento de Fibroblastos
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Glucuronidasa
Límite:
Animals
Idioma:
En
Año:
2016
Tipo del documento:
Article