Endothelium-targeted overexpression of heat shock protein 27 ameliorates blood-brain barrier disruption after ischemic brain injury.

Shi, Yejie; Jiang, Xiaoyan; Zhang, Lili; Pu, Hongjian; Hu, Xiaoming; Zhang, Wenting; Cai, Wei; Gao, Yanqin; Leak, Rehana K; Keep, Richard F; Bennett, Michael V L; Chen, Jun

Shi, Yejie; Jiang, Xiaoyan; Zhang, Lili; Pu, Hongjian; Hu, Xiaoming; Zhang, Wenting; Cai, Wei; Gao, Yanqin; Leak, Rehana K; Keep, Richard F; Bennett, Michael V L; Chen, Jun.

Afiliación

Shi Y; State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Jiang X; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15261.
Zhang L; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213.
Pu H; State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Hu X; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213.
Zhang W; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15261.
Cai W; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213.
Gao Y; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213.
Leak RK; State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.
Keep RF; Geriatric Research, Education and Clinical Center, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA 15261.
Bennett MV; Pittsburgh Institute of Brain Disorders & Recovery and Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15213.
Chen J; State Key Laboratory of Medical Neurobiology, Institute of Brain Sciences and Collaborative Innovation Center for Brain Science, Fudan University, Shanghai 200032, China.

Proc Natl Acad Sci U S A ; 114(7): E1243-E1252, 2017 02 14.

Article en En | MEDLINE | ID: mdl-28137866

Asunto(s)

Barrera Hematoencefálica/metabolismo; Encéfalo/metabolismo; Endotelio/metabolismo; Proteínas de Choque Térmico HSP27/metabolismo; Daño por Reperfusión/metabolismo; Actinas/metabolismo; Animales; Encéfalo/irrigación sanguínea; Células Cultivadas; Células Endoteliales/metabolismo; Proteínas de Choque Térmico HSP27/genética; Humanos; Ratones Endogámicos C57BL; Ratones Transgénicos; Actividad Motora/genética; Neuronas/metabolismo; Polimerizacion; Daño por Reperfusión/genética; Daño por Reperfusión/fisiopatología; Transgenes/genética

Palabras clave

HSP27; endothelial cell; neuroinflammation; stress fiber; tight junction

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Encéfalo / Barrera Hematoencefálica / Daño por Reperfusión / Endotelio / Proteínas de Choque Térmico HSP27 Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article

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