Increased incidence of mammary tumors in rats after direct or transplacental exposure to 3-hydroxyxanthine.
J Natl Cancer Inst
; 61(6): 1411-4, 1978 Dec.
Article
en En
| MEDLINE
| ID: mdl-281549
ABSTRACT
Rats were exposed directly or transplacentally to the carcinogenic purine N-oxide 3-hydroxyxanthine (3-OH-X). Among female noninbred Wistar rats given 3-OH-X sc, beginning at suckling or weaning ages, there was a significantly greater proportion of mammary tumor bearers and a higher mean number of mammary tumors per rat than among controls. This effect was seen even at low doses producing no other neoplasms such as hepatic carcinomas or fibrosarcomas and fibromas at the site of injection. Noninbred Sprague-Dawley rats, treated transplacentally with 3-OH-X by ip injection into pregnant females, also also had a significantly greater incidence of mammary tumors than did controls.
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Banco de datos:
MEDLINE
Asunto principal:
Xantinas
/
Neoplasias Mamarias Experimentales
Tipo de estudio:
Incidence_studies
/
Risk_factors_studies
Límite:
Animals
/
Pregnancy
Idioma:
En
Año:
1978
Tipo del documento:
Article