Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.

Ulmasov, Barbara; Neuschwander-Tetri, Brent A; Lai, Jinping; Monastyrskiy, Vladimir; Bhat, Trisha; Yates, Matthew P; Oliva, Jonathan; Prinsen, Michael J; Ruminski, Peter G; Griggs, David W

Ulmasov, Barbara; Neuschwander-Tetri, Brent A; Lai, Jinping; Monastyrskiy, Vladimir; Bhat, Trisha; Yates, Matthew P; Oliva, Jonathan; Prinsen, Michael J; Ruminski, Peter G; Griggs, David W.

Afiliación

Ulmasov B; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri.
Neuschwander-Tetri BA; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri.
Lai J; Department of Pathology, Saint Louis University, Saint Louis, Missouri.
Monastyrskiy V; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri.
Bhat T; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Saint Louis University, Saint Louis, Missouri.
Yates MP; Center for World Health and Medicine, Saint Louis University, Saint Louis, Missouri.
Oliva J; Center for World Health and Medicine, Saint Louis University, Saint Louis, Missouri.
Prinsen MJ; Center for World Health and Medicine, Saint Louis University, Saint Louis, Missouri.
Ruminski PG; Center for World Health and Medicine, Saint Louis University, Saint Louis, Missouri.
Griggs DW; Center for World Health and Medicine, Saint Louis University, Saint Louis, Missouri.

Cell Mol Gastroenterol Hepatol ; 2(4): 499-518, 2016 Jul.

Article en En | MEDLINE | ID: mdl-28174730

Palabras clave

CP, chronic pancreatitis; CTGF, connective tissue growth factor; CWHM, Center for World Health and Medicine; Col1a1, collagen type I α1; DMEM, Dulbecco's modified Eagle medium; DMSO, dimethyl sulfoxide; ECM, extracellular matrix; FBS, fetal bovine serum; IC50, median inhibitory concentration; Inflammation; LAP, latency-associated peptide; LTC-14, large T immortalized cells; MLEC, mink lung epithelial cell; MMP, matrix metallopeptidase; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PSC, pancreatic stellate cell; Pancreas; Peptidomimetic; RGD, arginine-glycine-aspartic acid; Signal Transduction; TGFB, transforming growth factor ß; mPSC, mouse pancreatic stellate cell; mRNA, messenger RNA; p-SMAD, phosphorylated SMAD; α-SMA, α-smooth muscle actin

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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2016 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Año: 2016 Tipo del documento: Article