Anti-prediabetic effect of rose hip (Rosa canina) extract in spontaneously diabetic Torii rats.
J Sci Food Agric
; 97(12): 3923-3928, 2017 Sep.
Article
en En
| MEDLINE
| ID: mdl-28182280
ABSTRACT
BACKGROUND:
Prediabetes, a high-risk state for developing diabetes showing impaired glucose tolerance but a normal fasting blood glucose level, has an increasing prevalence worldwide. However, no study investigating the prevention of impaired glucose tolerance at the prediabetic stage by anti-diabetic functional foods has been reported. Thus, the present study aimed to evaluate the anti-prediabetic effect of rose hip in a prediabetic rat model.RESULTS:
Spontaneously diabetic Torii (SDT) rats were supplemented with hot-water extract of rose hip at a dose of 100 mg kg-1 body weight day-1 for 12 weeks. The results obtained showed that the supplementation of rose hip extract improved impaired glucose tolerance, promoted insulin secretion, preserved pancreatic beta-cell function and suppressed plasma advanced glycation end-products formation of methylglyoxal-derived hydroimidazolone (MG-H1) residue and Nϵ -carboxymethyl-lysine residues (e.g. MG-H1, control 465.5 ± 43.8 versus rose hip 59.1 ± 13.0 pmol mg protein-1 , P < 0.05) in SDT rats at the prediabetic stage (12-20 weeks old).CONCLUSION:
The present study provides the first evidence showing that a hot-water extract of rose hip could exert an anti-prediabetic effect in a rat model. © 2017 Society of Chemical Industry.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Extractos Vegetales
/
Rosa
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Diabetes Mellitus Tipo 2
/
Hipoglucemiantes
Tipo de estudio:
Risk_factors_studies
Límite:
Animals
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Humans
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Male
Idioma:
En
Año:
2017
Tipo del documento:
Article