Reduced Immunoglobulin (Ig) G Response to Staphylococcus aureus in STAT3 Hyper-IgE Syndrome.

Stentzel, Sebastian; Hagl, Beate; Abel, Felicitas; Kahl, Barbara C; Rack-Hoch, Anita; Bröker, Barbara M; Renner, Ellen D

Stentzel, Sebastian; Hagl, Beate; Abel, Felicitas; Kahl, Barbara C; Rack-Hoch, Anita; Bröker, Barbara M; Renner, Ellen D.

Afiliación

Stentzel S; Department of Immunology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany.
Hagl B; University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.
Abel F; Environmental Medicine, UNIKA-T, Technical University of Munich and Helmholtz Zentrum München, Munich/Augsburg, Germany.
Kahl BC; University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.
Rack-Hoch A; Institute of Medical Microbiology, University Hospital Münster, Germany.
Bröker BM; University Children's Hospital, Dr von Haunersches Kinderspital, Ludwig Maximilian University, Munich, Germany.
Renner ED; Department of Immunology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany.

Clin Infect Dis ; 64(9): 1279-1282, 2017 05 01.

Article en En | MEDLINE | ID: mdl-28203787

ABSTRACT

ABSTRACT

STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

Asunto(s)

Anticuerpos Antibacterianos/sangre; Inmunoglobulina G/sangre; Síndrome de Job/complicaciones; Infecciones Estafilocócicas/inmunología; Staphylococcus aureus/inmunología; Adolescente; Adulto; Niño; Preescolar; Fibrosis Quística/complicaciones; Femenino; Humanos; Masculino; Persona de Mediana Edad; Adulto Joven

Palabras clave

HIES; S. aureus; STAT3; Th17; adaptive immunity; cystic fibrosis; hyper-IgE Syndrome; specific IgG

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Infecciones Estafilocócicas / Staphylococcus aureus / Inmunoglobulina G / Síndrome de Job / Anticuerpos Antibacterianos Límite: Adolescent / Adult / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Año: 2017 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google