Divalent Naphthalene Diimide Ligands Display High Selectivity for the Human Telomeric G-quadruplex in K+ Buffer.
Chemistry
; 23(29): 6953-6958, 2017 May 23.
Article
en En
| MEDLINE
| ID: mdl-28257554
ABSTRACT
Selective G-quadruplex ligands offer great promise for the development of anti-cancer therapies. A novel series of divalent cationic naphthalene diimide ligands that selectively bind to the hybrid form of the human telomeric G-quadruplex in K+ buffer are described herein. We demonstrate that an imidazolium-bearing mannoside-conjugate is the most selective ligand to date for this quadruplex against several other quadruplex and duplex structures. We also show that a similarly selective methylpiperazine-bearing ligand was more toxic to HeLa cancer cells than doxorubicin, whilst exhibiting three times less toxicity towards fetal lung fibroblasts WI-38.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Potasio
/
Telómero
/
G-Cuádruplex
/
Imidas
/
Naftalenos
Límite:
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article