Cost-effectiveness analysis of an 18-week exercise programme for patients with breast and colon cancer undergoing adjuvant chemotherapy: the randomised PACT study.
BMJ Open
; 7(3): e012187, 2017 03 06.
Article
en En
| MEDLINE
| ID: mdl-28264824
ABSTRACT
OBJECTIVE:
Meta-analyses show that exercise interventions during cancer treatment reduce cancer-related fatigue. However, little is known about the cost-effectiveness of such interventions. Here we aim to assess the cost-effectiveness of the 18-week physical activity during cancer treatment (PACT) intervention for patients with breast and colon cancer. The PACT trial showed beneficial effects for fatigue and physical fitness.DESIGN:
Cost-effectiveness analyses with a 9-month time horizon (18â weeks of intervention and 18â weeks of follow-up) within the randomised controlled multicentre PACT study.SETTING:
Outpatient clinics of 7 hospitals in the Netherlands (1 academic and 6 general hospitals)PARTICIPANTS:
204 patients with breast cancer and 33 with colon cancer undergoing adjuvant treatment including chemotherapy. INTERVENTION Supervised 1-hour aerobic and resistance exercise (twice per week for 18â weeks) or usual care. MAIN OUTCOMEMEASURES:
Costs, quality-adjusted life years (QALY) and the incremental cost-effectiveness ratio.RESULTS:
For colon cancer, the cost-effectiveness analysis showed beneficial effects of the exercise intervention with incremental costs savings of 4321 and QALY improvements of 0.03. 100% of bootstrap simulations indicated that the intervention is dominant (ie, cheaper and more effective). For breast cancer, the results did not indicate that the exercise intervention was cost-effective. Incremental costs were 2912, and the incremental effect was 0.01 QALY. At a Dutch threshold value of 20â 000 per QALY, the probability that the intervention is cost-effective was 2%.CONCLUSIONS:
Our results suggest that the 18-week exercise programme was cost-effective for colon cancer, but not for breast cancer. TRIAL REGISTRATION NUMBER ISRCTN43801571.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias de la Mama
/
Evaluación de Programas y Proyectos de Salud
/
Análisis Costo-Beneficio
/
Neoplasias del Colon
/
Terapia por Ejercicio
Tipo de estudio:
Clinical_trials
/
Evaluation_studies
/
Health_economic_evaluation
Límite:
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
Europa
Idioma:
En
Año:
2017
Tipo del documento:
Article