Engineering of the LysR family transcriptional regulator FkbR1 and its target gene to improve ascomycin production.

Song, Kejing; Wei, Liang; Liu, Jiao; Wang, Junhua; Qi, Haishan; Wen, Jianping

Song, Kejing; Wei, Liang; Liu, Jiao; Wang, Junhua; Qi, Haishan; Wen, Jianping.

Afiliación

Song K; Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education, Tianjin, 300072, People's Republic of China.
Wei L; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.
Liu J; Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education, Tianjin, 300072, People's Republic of China.
Wang J; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.
Qi H; Key Laboratory of System Bioengineering (Tianjin University), Ministry of Education, Tianjin, 300072, People's Republic of China.
Wen J; SynBio Research Platform, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.

Appl Microbiol Biotechnol ; 101(11): 4581-4592, 2017 Jun.

Article en En | MEDLINE | ID: mdl-28349163

Asunto(s)

Antibacterianos/biosíntesis; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Regulación Bacteriana de la Expresión Génica; Streptomyces/genética; Tacrolimus/análogos & derivados; Factores de Transcripción/genética; Factores de Transcripción/metabolismo; Inmunoprecipitación de Cromatina; ADN Intergénico; Ensayo de Cambio de Movilidad Electroforética; Eliminación de Gen; Genes Bacterianos; Prueba de Complementación Genética; Reacción en Cadena en Tiempo Real de la Polimerasa; Streptomyces/metabolismo; Tacrolimus/metabolismo

Palabras clave

Ascomycin; FkbR1; Streptomyces hygroscopicus var. ascomyceticus; Target gene; Transcriptional regulator

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Streptomyces / Proteínas Bacterianas / Factores de Transcripción / Regulación Bacteriana de la Expresión Génica / Tacrolimus / Antibacterianos Idioma: En Año: 2017 Tipo del documento: Article

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