Signal intensity change on unenhanced T1-weighted images in dentate nucleus and globus pallidus after multiple administrations of gadoxetate disodium: an intraindividual comparative study.
Eur Radiol
; 27(10): 4372-4378, 2017 Oct.
Article
en En
| MEDLINE
| ID: mdl-28357495
ABSTRACT
PURPOSE:
To investigate whether there is an increased signal intensity (SI) of dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted magnetic resonance imaging (MRI), in patients who had undergone multiple administrations of gadoxetate disodium. MATERIALS ANDMETHODS:
We retrospectevely included stage III melanoma patients, who had been previously enrolled in a trial of adjuvant therapy and who had undergone whole-body contrast-enhanced MRIs with gadoxetate disodium every three months for their follow-up. The SI ratios of DN-to-pons and GP-to-thalamus on unenhanced T1-weighted images were calculated. The difference in SI ratios between the first and the last MRI examinations was assessed and a linear mixed model was performed to detect how SI ratios varied with the number of administrations.RESULTS:
Eighteen patients were included in our study. The number of gadoxetate disodium administrations ranged from 2 to 18. Paired t-test did not show any significant difference in DN-to-pons (p=0.21) and GP-to-thalamus (p=0.09) SI ratios by the end of the study. DN-to-pons SI ratio and GP-to-thalamus SI ratio did not significantly increase with increasing the number of administrations (p=0.14 and p=0.06, respectively).CONCLUSION:
Multiple administrations of gadoxetate disodium are not associated with increased SI in DN and GP in the brain. KEY POINTS ⢠Gadolinium may deposit in the human brain after multiple GBCA administrations. ⢠Gadolinium deposition is associated with increased T1W signal intensity ⢠Increase in signal intensity is most apparent within the DN and GP ⢠Multiple administrations of gadoxetate disodium do not increase T1W signal.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Núcleos Cerebelosos
/
Medios de Contraste
/
Gadolinio DTPA
/
Globo Pálido
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
2017
Tipo del documento:
Article