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Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity.
Saleheen, Danish; Natarajan, Pradeep; Armean, Irina M; Zhao, Wei; Rasheed, Asif; Khetarpal, Sumeet A; Won, Hong-Hee; Karczewski, Konrad J; O'Donnell-Luria, Anne H; Samocha, Kaitlin E; Weisburd, Benjamin; Gupta, Namrata; Zaidi, Mozzam; Samuel, Maria; Imran, Atif; Abbas, Shahid; Majeed, Faisal; Ishaq, Madiha; Akhtar, Saba; Trindade, Kevin; Mucksavage, Megan; Qamar, Nadeem; Zaman, Khan Shah; Yaqoob, Zia; Saghir, Tahir; Rizvi, Syed Nadeem Hasan; Memon, Anis; Hayyat Mallick, Nadeem; Ishaq, Mohammad; Rasheed, Syed Zahed; Memon, Fazal-Ur-Rehman; Mahmood, Khalid; Ahmed, Naveeduddin; Do, Ron; Krauss, Ronald M; MacArthur, Daniel G; Gabriel, Stacey; Lander, Eric S; Daly, Mark J; Frossard, Philippe; Danesh, John; Rader, Daniel J; Kathiresan, Sekar.
Afiliación
  • Saleheen D; Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Natarajan P; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Armean IM; Center for Genomic Medicine, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
  • Zhao W; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Rasheed A; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Khetarpal SA; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Won HH; Department of Biostatistics and Epidemiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Karczewski KJ; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • O'Donnell-Luria AH; Institute for Translational Medicine and Therapeutics, Department of Genetics, and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Samocha KE; Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Samsung Medical Center, Seoul, Korea.
  • Weisburd B; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Gupta N; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Zaidi M; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Samuel M; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Imran A; Division of Genetics and Genomics, Boston Children's Hospital, Boston, Massachusetts, USA.
  • Abbas S; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Majeed F; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Ishaq M; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Akhtar S; Analytic and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Trindade K; Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
  • Mucksavage M; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Qamar N; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Zaman KS; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Yaqoob Z; Faisalabad Institute of Cardiology, Faisalabad, Pakistan.
  • Saghir T; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Rizvi SNH; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Memon A; Center for Non-Communicable Diseases, Karachi, Pakistan.
  • Hayyat Mallick N; Institute for Translational Medicine and Therapeutics, Department of Genetics, and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Ishaq M; Institute for Translational Medicine and Therapeutics, Department of Genetics, and Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
  • Rasheed SZ; National Institute of Cardiovascular Disorders, Karachi, Pakistan.
  • Memon FU; National Institute of Cardiovascular Disorders, Karachi, Pakistan.
  • Mahmood K; National Institute of Cardiovascular Disorders, Karachi, Pakistan.
  • Ahmed N; National Institute of Cardiovascular Disorders, Karachi, Pakistan.
  • Do R; National Institute of Cardiovascular Disorders, Karachi, Pakistan.
  • Krauss RM; National Institute of Cardiovascular Disorders, Karachi, Pakistan.
  • MacArthur DG; Punjab Institute of Cardiology, Lahore, Pakistan.
  • Gabriel S; Karachi Institute of Heart Diseases, Karachi, Pakistan.
  • Lander ES; Karachi Institute of Heart Diseases, Karachi, Pakistan.
  • Daly MJ; Red Crescent Institute of Cardiology, Hyderabad, Pakistan.
  • Frossard P; The Civil Hospital, Karachi, Pakistan.
  • Danesh J; Liaquat National Hospital, Karachi, Pakistan.
  • Rader DJ; Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
  • Kathiresan S; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Nature ; 544(7649): 235-239, 2017 04 12.
Article en En | MEDLINE | ID: mdl-28406212
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenotipo / Análisis Mutacional de ADN / Eliminación de Gen / Consanguinidad / Estudios de Asociación Genética / Genes / Homocigoto Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fenotipo / Análisis Mutacional de ADN / Eliminación de Gen / Consanguinidad / Estudios de Asociación Genética / Genes / Homocigoto Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Año: 2017 Tipo del documento: Article