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Discovery of potent and orally active 1,4-disubstituted indazoles as novel allosteric glucokinase activators.
Cheruvallath, Zacharia S; Gwaltney, Stephen L; Sabat, Mark; Tang, Mingnam; Wang, Haixia; Jennings, Andy; Hosfield, David; Lee, Bumsup; Wu, Yiqin; Halkowycz, Petro; Grimshaw, Charles E.
Afiliación
  • Cheruvallath ZS; Takeda California, 10410 Science Center Drive, San Diego 92121, USA. Electronic address: zacharia.cheruvallath@takedasd.com.
  • Gwaltney SL; Chrysalis Therapeutics, San Diego, CA 92121, USA.
  • Sabat M; Takeda California, 10410 Science Center Drive, San Diego 92121, USA.
  • Tang M; Takeda California, 10410 Science Center Drive, San Diego 92121, USA.
  • Wang H; Takeda California, 10410 Science Center Drive, San Diego 92121, USA.
  • Jennings A; Takeda California, 10410 Science Center Drive, San Diego 92121, USA.
  • Hosfield D; Ben May Cancer Institute, University of Chicago, USA.
  • Lee B; Kolon Life Science, Inc, 7FL Kolon Tower Annex, 38 Byeoryangsangga 2-Ro, Gwacheon-Si, Gyeonggi-Do 427-709, Republic of Korea.
  • Wu Y; Quanticel Pharmaceuticals Inc., 9393 Towne Centre Drive, Suite 110, San Diego, CA 92121, USA.
  • Halkowycz P; Takeda California, 10410 Science Center Drive, San Diego 92121, USA.
  • Grimshaw CE; Takeda California, 10410 Science Center Drive, San Diego 92121, USA.
Bioorg Med Chem Lett ; 27(12): 2678-2682, 2017 06 15.
Article en En | MEDLINE | ID: mdl-28512030
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activadores de Enzimas / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Descubrimiento de Drogas / Glucoquinasa / Indazoles Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Activadores de Enzimas / Diabetes Mellitus Experimental / Diabetes Mellitus Tipo 2 / Descubrimiento de Drogas / Glucoquinasa / Indazoles Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article