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Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors.
Hynes, John; Wu, Hong; Kempson, James; Duan, James J-W; Lu, Zhonghui; Jiang, Bin; Stachura, Sylwia; Tokarski, John S; Sack, John S; Khan, Javed A; Lippy, Jonathan S; Zhang, Rosemary F; Pitt, Sidney; Shen, Guoxiang; Gillooly, Kate; McIntyre, Kim; Carter, Percy H; Barrish, Joel C; Nadler, Steven G; Salter-Cid, Luisa M; Fura, Aberra; Schieven, Gary L; Pitts, William J; Wrobleski, Stephen T.
Afiliación
  • Hynes J; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA. Electronic address: john.hynes@bms.com.
  • Wu H; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Kempson J; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Duan JJ; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Lu Z; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Jiang B; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Stachura S; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Tokarski JS; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Sack JS; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Khan JA; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Lippy JS; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Zhang RF; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Pitt S; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Shen G; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Gillooly K; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • McIntyre K; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Carter PH; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Barrish JC; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Nadler SG; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Salter-Cid LM; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Fura A; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Schieven GL; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Pitts WJ; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
  • Wrobleski ST; Research and Development, Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, NJ 08543, USA.
Bioorg Med Chem Lett ; 27(14): 3101-3106, 2017 07 15.
Article en En | MEDLINE | ID: mdl-28539220
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridazinas / Pirroles / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 / Janus Quinasa 3 Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piridazinas / Pirroles / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 / Janus Quinasa 3 Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article