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Structure of human nSMase2 reveals an interdomain allosteric activation mechanism for ceramide generation.
Airola, Michael V; Shanbhogue, Prajna; Shamseddine, Achraf A; Guja, Kip E; Senkal, Can E; Maini, Rohan; Bartke, Nana; Wu, Bill X; Obeid, Lina M; Garcia-Diaz, Miguel; Hannun, Yusuf A.
Afiliación
  • Airola MV; Stony Brook University Cancer Center, Stony Brook, NY 11794.
  • Shanbhogue P; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794.
  • Shamseddine AA; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794.
  • Guja KE; Department of Medicine, Stony Brook University, Stony Brook, NY 11794.
  • Senkal CE; Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY 11794.
  • Maini R; Stony Brook University Cancer Center, Stony Brook, NY 11794.
  • Bartke N; Department of Medicine, Stony Brook University, Stony Brook, NY 11794.
  • Wu BX; Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794.
  • Obeid LM; Danone Nutricia Research, Singapore 138671.
  • Garcia-Diaz M; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425.
  • Hannun YA; Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425.
Proc Natl Acad Sci U S A ; 114(28): E5549-E5558, 2017 07 11.
Article en En | MEDLINE | ID: mdl-28652336
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Ceramidas / Sitio Alostérico Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Esfingomielina Fosfodiesterasa / Ceramidas / Sitio Alostérico Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article