Chemotherapy with radiotherapy influences time-to-development of radiation-induced sarcomas: a multicenter study.
Br J Cancer
; 117(3): 326-331, 2017 Jul 25.
Article
en En
| MEDLINE
| ID: mdl-28654633
ABSTRACT
BACKGROUND:
An increasing number and proportion of cancer patients with apparently localised disease are treated with chemotherapy and radiation therapy in contemporary oncology practice. In a pilot study of radiation-induced sarcoma (RIS) patients, we demonstrated that chemotherapy was associated with a reduced time to development of RIS. We now present a multi-centre collaborative study to validate this association.METHODS:
This was a retrospective cohort study of RIS cases across five large international sarcoma centres between 1 January 2000 to 31 December 2014. The primary endpoint was time to development of RIS.RESULTS:
We identified 419 patients with RIS. Chemotherapy for the first malignancy was associated with a shorter time to RIS development (HR 1.37; 95% CI 1.08-1.72; P=0.009). In the multi-variable model, older age (HR 2.11; 95% CI 1.83-2.43; P<0.001) and chemotherapy for the first malignancy (HR 1.61; 95% CI 1.26-2.05; P<0·001) were independently associated with a shorter time to RIS. Anthracyclines and alkylating agents significantly contribute to the effect.CONCLUSIONS:
This study confirms an association between chemotherapy given for the first malignancy and a shorter time to development of RIS.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Sarcoma
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Neoplasias Primarias Secundarias
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Antineoplásicos Alquilantes
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Neoplasias Inducidas por Radiación
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Antineoplásicos
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Año:
2017
Tipo del documento:
Article