[Microfluorimetric study of the effect of almitrine bismesylate (Vectarion) on intrapulmonary neuroepithelial bodies]. / Etude microfluorimétrique de l'action du bismésilate d'almitrine (Vectarion) sur les corps neuro-épithéliaux intrapulmonaires.
Rev Mal Respir
; 2 Suppl 1: S35-7, 1985.
Article
en Fr
| MEDLINE
| ID: mdl-2870545
ABSTRACT
As Almitrine bismesylate is a potent peripheral chemo-receptor stimulant we have studied its action, after intra-peritoneal injection, on the intra-neuro-epithelial bodies (NEB) of 24 young rabbits (4 to 17 days old) measuring the intensity of the cytoplasmic fluorescence. The administration of Almitrine bismesylate in pharmacological doses provoked a marked rise (around 25%) in the intensity of fluorescence of NEB compared to a placebo group, indicating a raised cytoplasmic concentration of serotonin. These observations show that Almitrine bismesylate, in stimulating all the peripheral chemo-receptors equally, influences the NEB at the same time corroborating the intra-pulmonary chemoreceptor mature of the latter. The mechanism of action of Almitrine bismesylate on the NEB remains unexplained at a cellular level. Some supplementary studies are planned to elucidate these aspects.
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Banco de datos:
MEDLINE
Asunto principal:
Piperazinas
/
Células Receptoras Sensoriales
/
Estimulantes del Sistema Nervioso Central
/
Pulmón
Límite:
Animals
Idioma:
Fr
Año:
1985
Tipo del documento:
Article