What Have We Learned About Movement Disorders from Functional Neurosurgery?
Annu Rev Neurosci
; 40: 453-477, 2017 07 25.
Article
en En
| MEDLINE
| ID: mdl-28772097
ABSTRACT
Modern functional neurosurgery for movement disorders such as Parkinson's disease, tremor, and dystonia involves the placement of focal lesions or the application of deep brain stimulation (DBS) within circuits that modulate motor function. Precise targeting of these motor structures can be further refined by the use of electrophysiological approaches. In particular, microelectrode recordings enable the delineation of neuroanatomic structures. In the course of these operations, there is an opportunity not only to map basal ganglia structures but also to gain insights into how disturbances in neural activity produce movement disorders. In this review, we aim to highlight what the field has uncovered thus far about movement disorders through DBS. The work to date lays the foundation for future studies that will shed further light on dysfunctional circuits mediating diseases of the nervous system and how we might modulate these circuits therapeutically.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Temblor
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Ganglios Basales
/
Trastornos Distónicos
Límite:
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article