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Endothelial cells, endoplasmic reticulum stress and oxysterols.
Luchetti, F; Crinelli, R; Cesarini, E; Canonico, B; Guidi, L; Zerbinati, C; Di Sario, G; Zamai, L; Magnani, M; Papa, S; Iuliano, L.
Afiliación
  • Luchetti F; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy. Electronic address: francesca.luchetti@uniurb.it.
  • Crinelli R; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Cesarini E; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Canonico B; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Guidi L; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Zerbinati C; Department of Medico-Surgical Sciences and Biotechnologies Vascular Biology, Atherothrombosis & Mass Spectrometry, Sapienza University of Rome, Latina, Italy.
  • Di Sario G; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Zamai L; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Magnani M; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Papa S; Departments of Biomolecular Sciences, University of Urbino Carlo Bo, Urbino, Italy.
  • Iuliano L; Department of Medico-Surgical Sciences and Biotechnologies Vascular Biology, Atherothrombosis & Mass Spectrometry, Sapienza University of Rome, Latina, Italy.
Redox Biol ; 13: 581-587, 2017 10.
Article en En | MEDLINE | ID: mdl-28783588
ABSTRACT
Oxysterols are bioactive lipids that act as regulators of lipid metabolism, inflammation, cell viability and are involved in several diseases, including atherosclerosis. Mounting evidence linked the atherosclerosis to endothelium dysfunction; in fact, the endothelium regulates the vascular system with roles in processes such as hemostasis, cell cholesterol, hormone trafficking, signal transduction and inflammation. Several papers shed light the ability of oxysterols to induce apoptosis in different cell lines including endothelial cells. Apoptotic endothelial cell and endothelial denudation may constitute a critical step in the transition to plaque erosion and vessel thrombosis, so preventing the endothelial damaged has garnered considerable attention as a novel means of treating atherosclerosis. Endoplasmic reticulum (ER) is the site where the proteins are synthetized and folded and is necessary for most cellular activity; perturbations of ER homeostasis leads to a condition known as endoplasmic reticulum stress. This condition evokes the unfolded protein response (UPR) an adaptive pathway that aims to restore ER homeostasis. Mounting evidence suggests that chronic activation of UPR leads to cell dysfunction and death and recently has been implicated in pathogenesis of endothelial dysfunction. Autophagy is an essential catabolic mechanism that delivers misfolded proteins and damaged organelles to the lysosome for degradation, maintaining basal levels of autophagic activity it is critical for cell survival. Several evidence suggests that persistent ER stress often results in stimulation of autophagic activities, likely as a compensatory mechanism to relieve ER stress and consequently cell death. In this review, we summarize evidence for the effect of oxysterols on endothelial cells, especially focusing on oxysterols-mediated induction of endoplasmic reticulum stress.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Endotelio Vascular / Células Endoteliales / Estrés del Retículo Endoplásmico / Oxiesteroles Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Endotelio Vascular / Células Endoteliales / Estrés del Retículo Endoplásmico / Oxiesteroles Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article