Association between periodontitis and severe asthma in adults: A case-control study.
Oral Dis
; 24(3): 442-448, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-28833877
ABSTRACT
OBJECTIVE:
To evaluate the association between periodontitis and severe asthma, with participants in treatment for severe asthma, controlled by therapy.METHODS:
A case-control investigation was performed to compare 130 adults with severe asthma with 130 without asthma. Individuals with periodontitis were those with ≥4 teeth with ≥1 site with probing depth ≥4 mm, clinical attachment level ≥3 mm, and bleeding upon probing at the same site. Severe asthma diagnosis was based on Global Initiative for Asthma criteria.RESULTS:
Association between exposure to periodontitis and severe asthma was found ORcrude = 2.98 (95% CI 1.74-5.11). When confounders were considered, the association between exposure to periodontitis and severe asthma was maintained ORadjusted = 3.01-3.25. Individuals with periodontitis had about a threefold increased risk of severe asthma than those without periodontitis. Frequency of periodontitis in participants with severe asthma was greater than that of those without asthma (46.6% vs 22.3%, p ≤ .05).CONCLUSIONS:
Association between periodontitis and severe asthma was observed. Further investigation is required to determine the direction of this relationship. It may be causal, but it may also be a consequence of the immunopathological process that characterizes asthma, or else, consequence of the medication used for treatment.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Periodontitis
/
Asma
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Año:
2018
Tipo del documento:
Article