Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses.
Drug Alcohol Depend
; 180: 68-75, 2017 11 01.
Article
en En
| MEDLINE
| ID: mdl-28881319
ABSTRACT
BACKGROUND:
Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects of acute cocaine administration on the blood concentrations of these hormones in cocaine users.METHODS:
We evaluated serum concentrations of six appetitive hormones ghrelin (total and acyl-ghrelin), amylin, glucagon-like peptide-1 (GLP-1), insulin, leptin and peptide YY (PYY), as well as acute cardiorespiratory and subjective responses of 8 experienced cocaine users who received 25mg intravenous (IV) cocaine.RESULTS:
Serum concentrations of GLP-1 (p=0.014) and PYY (p=0.036) were significantly decreased one hour following IV cocaine administration; there was a trend towards a decrease for insulin (p=0.055) and amylin (p=0.063) concentrations, while no significant IV cocaine effect was observed for ghrelin (total or acyl-ghrelin) or leptin concentrations (p'sâ«>0.5). We also observed associations between hormone concentrations acutely affected by IV cocaine (GLP-1, PYY, insulin, amylin) and some cocaine-related cardiorespiratory and subjective responses (e.g., increased heart and respiratory rates; feeling high and anxious).DISCUSSION:
These findings show a significant effect of acute IV cocaine administration on some appetitive hormones and suggest potential associations between these hormones and cocaine-related cardiorespiratory and subjective responses. Additional research is needed to further investigate the potential mechanisms underlining these associations.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Cocaína
/
Péptido YY
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Leptina
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Ingestión de Alimentos
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Péptido 1 Similar al Glucagón
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Ghrelina
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Polipéptido Amiloide de los Islotes Pancreáticos
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Insulina
Límite:
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article