Rational design of conformationally constrained oxazolidinone-fused 1,2,3,4-tetrahydroisoquinoline derivatives as potential PDE4 inhibitors.

Song, Gaopeng; Zhu, Xiang; Li, Junhua; Hu, Dekun; Zhao, Dongsheng; Liao, Yixian; Lin, Juntong; Zhang, Lian-Hui; Cui, Zi-Ning

Song, Gaopeng; Zhu, Xiang; Li, Junhua; Hu, Dekun; Zhao, Dongsheng; Liao, Yixian; Lin, Juntong; Zhang, Lian-Hui; Cui, Zi-Ning.

Afiliación

Song G; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China; College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Zhu X; Department of Infectious Diseases, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China.
Li J; College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Hu D; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China; Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural Univers
Zhao D; Department of Pharmacy, Quanzhou Medical College, Quanzhou 362100, China.
Liao Y; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China; College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China; Integrative Microbiology Research Centre, Guangdong Pro
Lin J; College of Materials and Energy, South China Agricultural University, Guangzhou 510642, China.
Zhang LH; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China; Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural Univers
Cui ZN; State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University, Guangzhou 510642, China; Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural Univers

Bioorg Med Chem ; 25(20): 5709-5717, 2017 10 15.

Article en En | MEDLINE | ID: mdl-28888661

Asunto(s)

Diseño de Fármacos; Tetrahidroisoquinolinas/síntesis química; Tetrahidroisoquinolinas/farmacología; Animales; Asma/tratamiento farmacológico; Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4/química; Fosfodiesterasas de Nucleótidos Cíclicos Tipo 4/metabolismo; Modelos Animales de Enfermedad; Humanos; Concentración 50 Inhibidora; Conformación Molecular; Simulación del Acoplamiento Molecular; Inhibidores de Fosfodiesterasa 4/síntesis química; Inhibidores de Fosfodiesterasa 4/química; Inhibidores de Fosfodiesterasa 4/farmacología; Inhibidores de Fosfodiesterasa 4/uso terapéutico; Enfermedad Pulmonar Obstructiva Crónica/tratamiento farmacológico; Rolipram/química; Rolipram/farmacología; Rolipram/uso terapéutico; Sepsis/tratamiento farmacológico; Relación Estructura-Actividad; Tetrahidroisoquinolinas/química; Tetrahidroisoquinolinas/uso terapéutico

Palabras clave

Conformational restriction; Molecular simulation; PDE4 inhibitor; Synthesis; Tetrahydroisoquinoline derivatives

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Tetrahidroisoquinolinas Límite: Animals / Humans Idioma: En Año: 2017 Tipo del documento: Article

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