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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Hall, Justin; Brault, Amy; Vincent, Fabien; Weng, Shawn; Wang, Hong; Dumlao, Darren; Aulabaugh, Ann; Aivazian, Dikran; Castro, Dana; Chen, Ming; Culp, Jeffrey; Dower, Ken; Gardner, Joseph; Hawrylik, Steven; Golenbock, Douglas; Hepworth, David; Horn, Mark; Jones, Lyn; Jones, Peter; Latz, Eicke; Li, Jing; Lin, Lih-Ling; Lin, Wen; Lin, David; Lovering, Frank; Niljanskul, Nootaree; Nistler, Ryan; Pierce, Betsy; Plotnikova, Olga; Schmitt, Daniel; Shanker, Suman; Smith, James; Snyder, William; Subashi, Timothy; Trujillo, John; Tyminski, Edyta; Wang, Guoxing; Wong, Jimson; Lefker, Bruce; Dakin, Leslie; Leach, Karen.
Afiliación
  • Hall J; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Brault A; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Vincent F; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Weng S; Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America.
  • Wang H; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Dumlao D; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Aulabaugh A; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Aivazian D; Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America.
  • Castro D; Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America.
  • Chen M; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Culp J; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Dower K; Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America.
  • Gardner J; External Research Solutions, Pfizer, Groton, Connecticut, United States of America.
  • Hawrylik S; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Golenbock D; University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
  • Hepworth D; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
  • Horn M; Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America.
  • Jones L; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
  • Jones P; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
  • Latz E; University of Massachusetts Medical School, Worcester, Massachusetts, United States of America.
  • Li J; Institute of Innate Immunity, University Hospitals Bonn, Bonn, Germany.
  • Lin LL; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
  • Lin W; Inflammation and Immunology, Pfizer, Cambridge, Massachusetts, United States of America.
  • Lin D; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Lovering F; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Niljanskul N; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
  • Nistler R; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Pierce B; Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America.
  • Plotnikova O; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Schmitt D; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Shanker S; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Smith J; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Snyder W; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Subashi T; Pfizer Centers for Therapeutic Innovation (CTI), San Diego, California, United States of America.
  • Trujillo J; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Tyminski E; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Wang G; Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America.
  • Wong J; Pfizer Centers for Therapeutic Innovation (CTI), Boston, Massachusetts, United States of America.
  • Lefker B; Medicine Design, Pfizer, Groton, Connecticut, United States of America.
  • Dakin L; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
  • Leach K; Medicine Design, Pfizer, Cambridge, Massachusetts, United States of America.
PLoS One ; 12(9): e0184843, 2017.
Article en En | MEDLINE | ID: mdl-28934246
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Inhibidores Enzimáticos / Nucleotidiltransferasas Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirazoles / Pirimidinas / Inhibidores Enzimáticos / Nucleotidiltransferasas Límite: Humans Idioma: En Año: 2017 Tipo del documento: Article