Vitamin D receptor protects glioblastoma A172 cells against Coxsackievirus A16 infection induced cell death in the pathogenesis of hand, foot, and mouth disease.
Biochem Biophys Res Commun
; 493(2): 952-956, 2017 11 18.
Article
en En
| MEDLINE
| ID: mdl-28943436
ABSTRACT
Hand, foot, and mouth disease (HFMD) was one of the most common children illnesses. Coxsackievirus A16 was one of the major pathogens that cause HFMD. However, the role of vitamin D underlying this common illness has not been elucidated. Our study examined that vitamin D levels was significantly lower in 33 HFMD patients, compared to 36 healthy children. Unexpectedly, both mRNA and protein expression of VDR were significantly decreased in CA16 infected glioblastoma A172 cells. And overexpression of VDR or vitamin D treatment in CA16 infected glioblastoma A172 cells could reverse the CA16 infection induced cell death, apoptosis or mitochondrial membrane rupture. Therefore, our study, for the first time, demonstrated that vitamin D and VDR could associate with the pathogenesis of HFMD. Thus might provide useful information for HFMD prevention and treatments.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Receptores de Calcitriol
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Enterovirus
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Infecciones por Coxsackievirus
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Enfermedad de Boca, Mano y Pie
Tipo de estudio:
Etiology_studies
Límite:
Child, preschool
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Humans
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Infant
Idioma:
En
Año:
2017
Tipo del documento:
Article