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Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer.
Robertson, A Gordon; Kim, Jaegil; Al-Ahmadie, Hikmat; Bellmunt, Joaquim; Guo, Guangwu; Cherniack, Andrew D; Hinoue, Toshinori; Laird, Peter W; Hoadley, Katherine A; Akbani, Rehan; Castro, Mauro A A; Gibb, Ewan A; Kanchi, Rupa S; Gordenin, Dmitry A; Shukla, Sachet A; Sanchez-Vega, Francisco; Hansel, Donna E; Czerniak, Bogdan A; Reuter, Victor E; Su, Xiaoping; de Sa Carvalho, Benilton; Chagas, Vinicius S; Mungall, Karen L; Sadeghi, Sara; Pedamallu, Chandra Sekhar; Lu, Yiling; Klimczak, Leszek J; Zhang, Jiexin; Choo, Caleb; Ojesina, Akinyemi I; Bullman, Susan; Leraas, Kristen M; Lichtenberg, Tara M; Wu, Catherine J; Schultz, Nicholaus; Getz, Gad; Meyerson, Matthew; Mills, Gordon B; McConkey, David J; Weinstein, John N; Kwiatkowski, David J; Lerner, Seth P.
Afiliación
  • Robertson AG; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Kim J; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Al-Ahmadie H; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Bellmunt J; PSMAR-IMIM Lab, Bladder Cancer Center, Department of Medicine, Dana-Farber Cancer Institute and Harvard University, Boston, MA 02215, USA.
  • Guo G; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard University, Boston, MA 02115, USA.
  • Cherniack AD; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Hinoue T; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Laird PW; Center for Epigenetics, Van Andel Research Institute, Grand Rapids, MI 49503, USA.
  • Hoadley KA; Department of Genetics, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27514, USA.
  • Akbani R; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Castro MAA; Bioinformatics and Systems Biology Laboratory, Federal University of Paraná Polytechnic Center, Curitiba, PR CEP 80.060-000, Brazil.
  • Gibb EA; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Kanchi RS; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Gordenin DA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
  • Shukla SA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard University, Boston, MA 02115, USA.
  • Sanchez-Vega F; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Hansel DE; Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
  • Czerniak BA; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Reuter VE; Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Su X; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • de Sa Carvalho B; Biostatistics and Computational Biology Laboratory, Department of Statistics, University of Campinas, São Paulo, 13.083-859, Brazil.
  • Chagas VS; Bioinformatics and Systems Biology Laboratory, Federal University of Paraná Polytechnic Center, Curitiba, PR CEP 80.060-000, Brazil.
  • Mungall KL; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Sadeghi S; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Pedamallu CS; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Lu Y; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Klimczak LJ; Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC 27709, USA.
  • Zhang J; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • Choo C; Canada's Michael Smith Genome Sciences Center, BC Cancer Agency, Vancouver, BC V5Z 4S6, Canada.
  • Ojesina AI; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
  • Bullman S; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Leraas KM; Biospecimen Core Resource, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
  • Lichtenberg TM; Biospecimen Core Resource, The Research Institute at Nationwide Children's Hospital, Columbus, OH 43205, USA.
  • Wu CJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
  • Schultz N; Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
  • Getz G; Cancer Program, The Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
  • Meyerson M; Pathology and Medical Oncology, Dana-Farber Cancer Institute and Harvard University, Boston, MA 02115, USA.
  • Mills GB; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
  • McConkey DJ; Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Weinstein JN; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 USA. Electronic address: jweinste@mdanderson.org.
  • Kwiatkowski DJ; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: dk@rics.bwh.harvard.edu.
  • Lerner SP; Scott Department of Urology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: slerner@bcm.edu.
Cell ; 171(3): 540-556.e25, 2017 Oct 19.
Article en En | MEDLINE | ID: mdl-28988769
ABSTRACT
We report a comprehensive analysis of 412 muscle-invasive bladder cancers characterized by multiple TCGA analytical platforms. Fifty-eight genes were significantly mutated, and the overall mutational load was associated with APOBEC-signature mutagenesis. Clustering by mutation signature identified a high-mutation subset with 75% 5-year survival. mRNA expression clustering refined prior clustering analyses and identified a poor-survival "neuronal" subtype in which the majority of tumors lacked small cell or neuroendocrine histology. Clustering by mRNA, long non-coding RNA (lncRNA), and miRNA expression converged to identify subsets with differential epithelial-mesenchymal transition status, carcinoma in situ scores, histologic features, and survival. Our analyses identified 5 expression subtypes that may stratify response to different treatments.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Middle aged Idioma: En Año: 2017 Tipo del documento: Article
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias de la Vejiga Urinaria Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Middle aged Idioma: En Año: 2017 Tipo del documento: Article