Synthesis and anticonvulsant properties of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones.
J Med Chem
; 32(1): 93-5, 1989 Jan.
Article
en En
| MEDLINE
| ID: mdl-2909750
ABSTRACT
A series of 2,3,3a,4-tetrahydro-1H-pyrrolo[1,2-a]benzimidazol-1-ones were synthesized and evaluated for anticonvulsant activity in DBA/2 mice against sound-induced seizures and in rats against maximal electroshock-induced seizures. Most of the derivatives showed an anticonvulsant effect better than that of valproate, a commonly used anticonvulsant drug. Compound 3 possessed an anticonvulsant activity comparable to that of diphenylhydantoin in both tests and was selected for further studies. Structure-activity relationships are discussed.
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Banco de datos:
MEDLINE
Asunto principal:
Pirrolidinonas
/
Bencimidazoles
/
Anticonvulsivantes
Límite:
Animals
Idioma:
En
Año:
1989
Tipo del documento:
Article