Hepatocyte-specific deletion of BAP31 promotes SREBP1C activation, promotes hepatic lipid accumulation, and worsens IR in mice.

Xu, Jia-Lin; Li, Li-Ya; Wang, Yan-Qing; Li, Ya-Qi; Shan, Mu; Sun, Shi-Zhuo; Yu, Yang; Wang, Bing

Xu, Jia-Lin; Li, Li-Ya; Wang, Yan-Qing; Li, Ya-Qi; Shan, Mu; Sun, Shi-Zhuo; Yu, Yang; Wang, Bing.

Afiliación

Xu JL; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China.
Li LY; Microbial Pharmaceuticals, College of Life and Health Sciences, Northeastern University, Shenyang 110169, People's Republic of China.
Wang YQ; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China.
Li YQ; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China.
Shan M; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China.
Sun SZ; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China.
Yu Y; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China.
Wang B; Institutes of Biochemistry and Molecular Biology Northeastern University, Shenyang 110169, People's Republic of China wangbing@mail.neu.edu.cn.

J Lipid Res ; 59(1): 35-47, 2018 01.

Article en En | MEDLINE | ID: mdl-29113994

Asunto(s)

Hepatocitos/metabolismo; Resistencia a la Insulina; Lípidos/análisis; Hígado/metabolismo; Proteínas de la Membrana/deficiencia; Proteína 1 de Unión a los Elementos Reguladores de Esteroles/metabolismo; Animales; Dieta Alta en Grasa/efectos adversos; Células Hep G2; Hepatocitos/patología; Humanos; Lípidos/genética; Hígado/patología; Masculino; Proteínas de la Membrana/genética; Proteínas de la Membrana/metabolismo; Ratones; Ratones Endogámicos C57BL; Ratones Noqueados; Obesidad/inducido químicamente; Obesidad/metabolismo; Células Tumorales Cultivadas

Palabras clave

B-cell activated protein 31; B-cell associated protein 31; diabetes; endoplasmic reticulum stress; insulin resistance; liver steatosis; sterol regulatory element-binding protein 1C

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Resistencia a la Insulina / Hepatocitos / Proteína 1 de Unión a los Elementos Reguladores de Esteroles / Lípidos / Hígado / Proteínas de la Membrana Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Año: 2018 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google