Neural circuits of eating behaviour: Opportunities for therapeutic development.
J Psychopharmacol
; 31(11): 1388-1402, 2017 11.
Article
en En
| MEDLINE
| ID: mdl-29132237
ABSTRACT
Understanding of the neural and physiological substrates of hunger and satiety has increased rapidly over the last three decades, and pharmacological targets have already been identified for the treatment of obesity that has moved from pre-clinical screening to therapies approved by regulatory authorities. Initially, this review describes the way in which physiological signals of energy availability interact with hedonic and rewarding properties of food to modulate the neural circuitry that supports eating behaviour. This is followed by a brief account of current and promising targets for drug development and a review of the wide range of preclinical paradigms that model important influences on human eating behaviour, and can be used to guide early stages of the drug development process.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Ingestión de Alimentos
/
Conducta Alimentaria
Límite:
Animals
/
Humans
Idioma:
En
Año:
2017
Tipo del documento:
Article