LRP1 regulates peroxisome biogenesis and cholesterol homeostasis in oligodendrocytes and is required for proper CNS myelin development and repair.

Lin, Jing-Ping; Mironova, Yevgeniya A; Shrager, Peter; Giger, Roman J

Lin, Jing-Ping; Mironova, Yevgeniya A; Shrager, Peter; Giger, Roman J.

Afiliación

Lin JP; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, United States.
Mironova YA; Cellular and Molecular Biology Graduate Program, University of Michigan Medical School, Ann Arbor, MI, United States.
Shrager P; Department of Neuroscience, University of Rochester Medical Center, Rochester, NY, United States.
Giger RJ; Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI, United States.

Elife ; 62017 12 18.

Article en En | MEDLINE | ID: mdl-29251594

Asunto(s)

Colesterol/metabolismo; Homeostasis; Vaina de Mielina/metabolismo; Células Precursoras de Oligodendrocitos/fisiología; Biogénesis de Organelos; Peroxisomas/metabolismo; Receptores de LDL/metabolismo; Proteínas Supresoras de Tumor/metabolismo; Animales; Diferenciación Celular; Células Cultivadas; Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad; Ratones

Palabras clave

CNS Myelin Repair; Cholesterol Homeostasis; LRP1; Oligodendrocyte differentiation; Peroxisome Biogenesis; mouse; neuroscience

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Biogénesis de Organelos / Receptores de LDL / Colesterol / Peroxisomas / Proteínas Supresoras de Tumor / Células Precursoras de Oligodendrocitos / Homeostasis / Vaina de Mielina Límite: Animals Idioma: En Año: 2017 Tipo del documento: Article

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