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Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
Vazquez, Michael L; Kaila, Neelu; Strohbach, Joseph W; Trzupek, John D; Brown, Matthew F; Flanagan, Mark E; Mitton-Fry, Mark J; Johnson, Timothy A; TenBrink, Ruth E; Arnold, Eric P; Basak, Arindrajit; Heasley, Steven E; Kwon, Soojin; Langille, Jonathan; Parikh, Mihir D; Griffin, Sarah H; Casavant, Jeffrey M; Duclos, Brian A; Fenwick, Ashley E; Harris, Thomas M; Han, Seungil; Caspers, Nicole; Dowty, Martin E; Yang, Xin; Banker, Mary Ellen; Hegen, Martin; Symanowicz, Peter T; Li, Li; Wang, Lu; Lin, Tsung H; Jussif, Jason; Clark, James D; Telliez, Jean-Baptiste; Robinson, Ralph P; Unwalla, Ray.
Afiliación
  • Vazquez ML; Medicine Design, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Kaila N; Medicine Design, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Strohbach JW; Medicine Design, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Trzupek JD; Medicine Design, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Brown MF; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Flanagan ME; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Mitton-Fry MJ; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Johnson TA; Veterinary Medicine Research and Development, Pfizer Inc , 333 Portage Street, Kalamazoo, Michigan 49007, United States.
  • TenBrink RE; Medicinal Chemistry, Pfizer Inc , 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, United States.
  • Arnold EP; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Basak A; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Heasley SE; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Kwon S; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Langille J; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Parikh MD; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Griffin SH; Chemical Research Development, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Casavant JM; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Duclos BA; Veterinary Medicine Research and Development, Pfizer Inc , 333 Portage Street, Kalamazoo, Michigan 49007, United States.
  • Fenwick AE; Veterinary Medicine Research and Development, Pfizer Inc , 333 Portage Street, Kalamazoo, Michigan 49007, United States.
  • Harris TM; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Han S; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Caspers N; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Dowty ME; Medicine Design, Pfizer Inc , 1 Burtt Road, Andover, Massachusetts 01810, United States.
  • Yang X; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Banker ME; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Hegen M; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Symanowicz PT; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Li L; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Wang L; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Lin TH; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Jussif J; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Clark JD; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Telliez JB; Inflammation and Immunology, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
  • Robinson RP; Medicine Design, Pfizer Inc , Eastern Point Road, Groton, Connecticut 06340, United States.
  • Unwalla R; Medicine Design, Pfizer Inc , 1 Portland Street, Cambridge, Massachusetts 02139, United States.
J Med Chem ; 61(3): 1130-1152, 2018 02 08.
Article en En | MEDLINE | ID: mdl-29298069
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Enfermedades Autoinmunes / Sulfonamidas / Ciclobutanos / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / Pirroles / Enfermedades Autoinmunes / Sulfonamidas / Ciclobutanos / Inhibidores de Proteínas Quinasas / Janus Quinasa 1 Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article