Is the body composition development in premature infants associated with a distinctive nuclear magnetic resonance metabolomic profiling of urine?
J Matern Fetal Neonatal Med
; 32(14): 2310-2318, 2019 Jul.
Article
en En
| MEDLINE
| ID: mdl-29357769
ABSTRACT
OBJECTIVE:
Preterm infants' body composition at term-corrected age differs from that of term infants but appears to be similar at the age of 3 months. The aim of this study was to compare the metabolomic pattern of preterm infants at term and at 3 months with that of term infants and to determine its association with body composition development.METHOD:
We designed a pilot study. Growth and body composition were evaluated by an air displacement plethysmography system in 13 preterm infants and seven term newborns at term and at 3 months of corrected age. Urine samples were collected at the same time points and analysed by nuclear magnetic resonance.RESULTS:
At term-corrected age, preterm infants showed a higher fat mass percentage compared with that of term newborns, whereas at 3 months of corrected age, the body composition parameters were similar between the groups. At the first time point, nuclear magnetic resonance analysis showed a urinary increase in choline/phosphocholine, betaine and glucose in preterm infants. At the second time point, the preterm group exhibited a urinary increase in choline/phosphocholine and a decrease in betaine.CONCLUSIONS:
The increased urinary excretion of choline, a betaine precursor, could reflect a potential altered metabolism in preterm infants.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Orina
/
Composición Corporal
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Recien Nacido Prematuro
/
Recién Nacido de muy Bajo Peso
Tipo de estudio:
Observational_studies
/
Risk_factors_studies
Límite:
Humans
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Infant
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Newborn
Idioma:
En
Año:
2019
Tipo del documento:
Article