Phytochemical analysis and antibacterial activity of methanolic extract of Bergenia purpurascens against common respiratory infection causing bacterial species in vitro and in neonatal rats.
Microb Pathog
; 117: 315-319, 2018 Apr.
Article
en En
| MEDLINE
| ID: mdl-29366865
ABSTRACT
Respiratory bacterial infections are responsible for significant mortality across the world and with emergence of drug resistant bacterial strains there is urgent need to look for new treatment options. In this study we evaluated the antimicrobial activity of methanolic extract of Bergenia purpurasceus in vitro and in neonatal rats. The results of the present study revealed that the methanolic extract exhibits antimicrobial activity against all the bacterial species with MIC ranging from 75 to 150⯵g/ml. The antibacterial activity of the Bergenia purpurasceus extract was also determined in the neonatal rat models wherein it was observed that administration of 50 and 100â¯mg/kg doses of Bergenia purpurasceus extract improved the survival of the neonatal rats infected with S. aureus. Furthermore, the extract showed considerable antioxidant activity which was positively associated with the phenolics and flavonoids content. Finally the constituents responsible for the bioactivity of the extract were identified and found to be bergenin, catechin, naringenin, myricetin and gallic acid. Takentogether, these results indicate that Bergenia purpurasceus extract could prove useful for the treatment of bacterial respiratory infections.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Infecciones del Sistema Respiratorio
/
Medicamentos Herbarios Chinos
/
Extractos Vegetales
/
Saxifragaceae
/
Metanol
/
Fitoquímicos
/
Antibacterianos
Límite:
Animals
Idioma:
En
Año:
2018
Tipo del documento:
Article