[Non-Small Cell Lung Cancer - Development of Parallel Mechanisms of Resistance]. / Nicht kleinzelliges Lungenkarzinom ­ doppelte Resistenzentwicklung.

ABSTRACT

Acquired resistances to tyrosine kinase inhibitors in non-small cell lung cancer develop after 9 - 12 month. In 60 % of the cases these resistances arise because of a secondary EGFR-T790 M resistance mutation. This report is describing the case of a patient who developed parallel two different mechanisms of resistance A T790 M resistance mutation and a transformation into a small cell neuroendocrine cancer. Under therapy with Osimertinib and chemotherapy with carboplatin and etoposide the tumor responsed partially.