Skeletal Muscle Pump Function Is Associated With Exercise Capacity in Patients With Heart Failure.
Circ J
; 82(4): 1033-1040, 2018 03 23.
Article
en En
| MEDLINE
| ID: mdl-29491319
ABSTRACT
BACKGROUND:
Skeletal muscle pump function may play a key role in maintaining cardiac output (CO), because of the lack of cardiac contractility reserve during incremental exercise in heart failure (HF) patients. We aimed to investigate the relationship between lower leg pump function and surrogate measures of CO during cardiopulmonary exercise testing (CPX) in HF patients.MethodsâandâResults:
Consecutive cardiac patients referred for CPX had their lower leg ejection fraction (LgEF) measured using strain gauge plethysmography as a marker of skeletal muscle pump function. We analyzed 88 patients, including 65 HF patients and 23 control subjects. Unlike the control subjects, LgEF correlated with peak oxygen consumption (VÌO2) and peak oxygen (O2) pulse (peak VÌO2 r=0.280, P=0.024; peak O2 pulse r=0.540, P<0.001) in HF patients. Significant relationships among LgEF, peak VÌO2, and peak O2 pulse were observed in HF patients with reduced EF (peak VÌO2 r=0.367, P=0.026; peak O2 pulse r=0.658, P<0.001), whereas LgEF in HF patients with preserved EF showed a weak correlation only with peak O2 pulse (r=0.407, P=0.032). LgEF was selected as an independent determinant of peak VÌO2 (ß=0.187, P=0.036) and peak O2 pulse (ß=0.520, P<0.001) in HF patients.CONCLUSIONS:
Lower leg skeletal muscle function may contribute to exercise capacity through an indirect mechanism on cardiac function in HF.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Tolerancia al Ejercicio
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Músculo Esquelético
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Insuficiencia Cardíaca
Tipo de estudio:
Observational_studies
Límite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2018
Tipo del documento:
Article