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The Discovery of ( S)-1-(6-(3-((4-(1-(Cyclopropanecarbonyl)piperidin-4-yl)-2-methylphenyl)amino)-2,3-dihydro-1 H-inden-4-yl)pyridin-2-yl)-5-methyl-1 H-pyrazole-4-carboxylic Acid, a Soluble Guanylate Cyclase Activator Specifically Designed for Topical Ocular Delivery as a Therapy for Glaucoma.
Ehara, Takeru; Adams, Christopher M; Bevan, Doug; Ji, Nan; Meredith, Erik L; Belanger, David B; Powers, James; Kato, Mitsunori; Solovay, Catherine; Liu, Donglei; Capparelli, Michael; Bolduc, Philippe; Grob, Jonathan E; Daniels, Matthew H; Ferrara, Luciana; Yang, Louis; Li, Byron; Towler, Christopher S; Stacy, Rebecca C; Prasanna, Ganesh; Mogi, Muneto.
Afiliación
  • Ehara T; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Adams CM; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Bevan D; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Ji N; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Meredith EL; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Belanger DB; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Powers J; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Kato M; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Solovay C; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Liu D; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Capparelli M; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Bolduc P; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Grob JE; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Daniels MH; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Ferrara L; Ophthalmology Research , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Yang L; Ophthalmology Research , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Li B; Ophthalmology Research , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Towler CS; Chemical and Pharmaceutical Profiling , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Stacy RC; Translational Medicine , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Prasanna G; Ophthalmology Research , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
  • Mogi M; Global Discovery Chemistry , Novartis Institutes for BioMedical Research, Inc. , Cambridge , Massachusetts 02139 , United States.
J Med Chem ; 61(6): 2552-2570, 2018 03 22.
Article en En | MEDLINE | ID: mdl-29498522
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glaucoma / Activadores de Enzimas / Guanilil Ciclasa Soluble Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Glaucoma / Activadores de Enzimas / Guanilil Ciclasa Soluble Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article