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Photodisruption of the Structurally Conserved Cys-Cys-Trp Triads Leads to Reduction-Resistant Scrambled Intrachain Disulfides in an IgG1 Monoclonal Antibody.
Wecksler, Aaron T; Yin, Jian; Lee Tao, Paula; Kabakoff, Bruce; Sreedhara, Alavattam; Deperalta, Galahad.
Afiliación
  • Wecksler AT; Protein Analytical Chemistry Department , Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Yin J; Early Stage Pharmaceutical Development , Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Lee Tao P; Protein Analytical Chemistry Department , Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Kabakoff B; Early Stage Pharmaceutical Development , Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Sreedhara A; Late Stage Pharmaceutical Development , Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
  • Deperalta G; Protein Analytical Chemistry Department , Genentech Inc. , 1 DNA Way , South San Francisco , California 94080 , United States.
Mol Pharm ; 15(4): 1598-1606, 2018 04 02.
Article en En | MEDLINE | ID: mdl-29502420
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triptófano / Resinas Acrílicas / Inmunoglobulina G / Cisteína / Dipéptidos / Anticuerpos Monoclonales Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
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XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Triptófano / Resinas Acrílicas / Inmunoglobulina G / Cisteína / Dipéptidos / Anticuerpos Monoclonales Idioma: En Año: 2018 Tipo del documento: Article