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Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.
Rohde, Jason M; Brimacombe, Kyle R; Liu, Li; Pacold, Michael E; Yasgar, Adam; Cheff, Dorian M; Lee, Tobie D; Rai, Ganesha; Baljinnyam, Bolormaa; Li, Zhuyin; Simeonov, Anton; Hall, Matthew D; Shen, Min; Sabatini, David M; Boxer, Matthew B.
Afiliación
  • Rohde JM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA. Electronic address: jason.rohde@nih.gov.
  • Brimacombe KR; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Liu L; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Pacold ME; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 0
  • Yasgar A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Cheff DM; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Lee TD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Rai G; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Baljinnyam B; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Li Z; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Simeonov A; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Hall MD; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Shen M; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
  • Sabatini DM; Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA; Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, 77 Massachusetts Avenue, Cambridge, MA 0
  • Boxer MB; National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, MD 20850, USA.
Bioorg Med Chem ; 26(8): 1727-1739, 2018 05 01.
Article en En | MEDLINE | ID: mdl-29555419
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperazinas / Tiourea / Inhibidores Enzimáticos / Fosfoglicerato-Deshidrogenasa Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article
Texto completo
Imprimir
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Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Piperazinas / Tiourea / Inhibidores Enzimáticos / Fosfoglicerato-Deshidrogenasa Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article