Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance.

Kwon, Hayeong; Jang, Donghwan; Choi, Moonjeong; Lee, Jaewoong; Jeong, Kyuho; Pak, Yunbae

Kwon, Hayeong; Jang, Donghwan; Choi, Moonjeong; Lee, Jaewoong; Jeong, Kyuho; Pak, Yunbae.

Afiliación

Kwon H; Division of Life Science, Graduate School of Applied Life Science (BK21 Plus Program), PMBBRC, Gyeongsang National University, Jinju 52828, Republic of Korea.
Jang D; Division of Life Science, Graduate School of Applied Life Science (BK21 Plus Program), PMBBRC, Gyeongsang National University, Jinju 52828, Republic of Korea.
Choi M; Division of Life Science, Graduate School of Applied Life Science (BK21 Plus Program), PMBBRC, Gyeongsang National University, Jinju 52828, Republic of Korea.
Lee J; Division of Life Science, Graduate School of Applied Life Science (BK21 Plus Program), PMBBRC, Gyeongsang National University, Jinju 52828, Republic of Korea.
Jeong K; Division of Life Science, Graduate School of Applied Life Science (BK21 Plus Program), PMBBRC, Gyeongsang National University, Jinju 52828, Republic of Korea.
Pak Y; Division of Life Science, Graduate School of Applied Life Science (BK21 Plus Program), PMBBRC, Gyeongsang National University, Jinju 52828, Republic of Korea. Electronic address: ybpak@gnu.ac.kr.

Biochim Biophys Acta Mol Basis Dis ; 1864(6 Pt A): 2169-2182, 2018 06.

Article en En | MEDLINE | ID: mdl-29604334

Asunto(s)

Antígenos CD/metabolismo; Caveolina 2/metabolismo; Resistencia a la Insulina/genética; Iniciación de la Cadena Peptídica Traduccional/genética; Proteína Tirosina Fosfatasa no Receptora Tipo 1/metabolismo; Receptor de Insulina/metabolismo; Células 3T3; Animales; Antígenos CD/genética; Caveolina 2/genética; Codón Iniciador/genética; Endocitosis; Células HEK293; Humanos; Lisosomas/metabolismo; Ratones; Mutagénesis Sitio-Dirigida; Iniciación de la Cadena Peptídica Traduccional/efectos de los fármacos; Fosforilación; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Proteína Tirosina Fosfatasa no Receptora Tipo 1/genética; Proteolisis; Interferencia de ARN; ARN Interferente Pequeño/metabolismo; Receptor de Insulina/genética

Palabras clave

Alternative translation initiation; Caveolin-2; Insulin receptor; Insulin resistance; Lysosomal degradation; Protein tyrosine phosphatase 1B

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Iniciación de la Cadena Peptídica Traduccional / Resistencia a la Insulina / Receptor de Insulina / Antígenos CD / Caveolina 2 / Proteína Tirosina Fosfatasa no Receptora Tipo 1 Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2018 Tipo del documento: Article

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