Effect of altered solution conditions on tau conformational dynamics: Plausible implication on order propensity and aggregation.

Jebarupa, Benita; Muralidharan, Monita; Srinivasu, Bindu Y; Mandal, Amit Kumar; Mitra, Gopa

Jebarupa, Benita; Muralidharan, Monita; Srinivasu, Bindu Y; Mandal, Amit Kumar; Mitra, Gopa.

Afiliación

Jebarupa B; Clinical Proteomics Unit, Division of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, 100 Feet Road, Koramangala, Bangalore 560034, Karnataka, India.
Muralidharan M; Clinical Proteomics Unit, Division of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, 100 Feet Road, Koramangala, Bangalore 560034, Karnataka, India.
Srinivasu BY; Clinical Proteomics Unit, Division of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, 100 Feet Road, Koramangala, Bangalore 560034, Karnataka, India.
Mandal AK; Clinical Proteomics Unit, Division of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, 100 Feet Road, Koramangala, Bangalore 560034, Karnataka, India.
Mitra G; Clinical Proteomics Unit, Division of Molecular Medicine, St. John's Research Institute, St. John's National Academy of Health Sciences, 100 Feet Road, Koramangala, Bangalore 560034, Karnataka, India. Electronic address: gopa@sjri.res.in.

Biochim Biophys Acta Proteins Proteom ; 1866(5-6): 668-679, 2018.

Article en En | MEDLINE | ID: mdl-29630971

Asunto(s)

Proteínas Intrínsecamente Desordenadas/química; Agregado de Proteínas; Agregación Patológica de Proteínas; Solventes/química; Proteínas tau/química; Humanos; Proteínas Intrínsecamente Desordenadas/genética; Concentración Osmolar; Conformación Proteica; Estabilidad Proteica; Proteolisis; Proteínas Recombinantes/química; Espectrometría de Masa por Ionización de Electrospray; Relación Estructura-Actividad; Temperatura; Proteínas tau/genética

Palabras clave

Conformational dynamics; Fibrillation; Intact mass spectrometry; Intrinsically disordered protein; Limited proteolysis; Tau

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Solventes / Proteínas tau / Proteínas Intrínsecamente Desordenadas / Agregación Patológica de Proteínas / Agregado de Proteínas Límite: Humans Idioma: En Año: 2018 Tipo del documento: Article

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