H1N1pdm09 Influenza Virus and Its Descendants Lack Extra-epitopic Amino Acid Residues Associated With Reduced Recognition by M158-66-Specific CD8+ T Cells.
J Infect Dis
; 218(4): 581-585, 2018 07 13.
Article
en En
| MEDLINE
| ID: mdl-29659927
ABSTRACT
Extra-epitopic amino acid residues affect recognition of human influenza A viruses (IAVs) by CD8+ T-lymphocytes (CTLs) specific for the highly conserved HLA-A*0201 restricted M158-66 epitope located in the matrix 1 (M1) protein. These residues are absent in the M1 protein of the 2009-pandemic IAV (H1N1pdm09). Consequently, stimulation with M1 protein of H1N1pdm09 IAV resulted in stronger activation and lytic activity of M158-66-specific CTLs than stimulation with seasonal H3N2 IAVs. During >6 years of circulation in the human population, descendants of the H1N1pdm09 virus had accumulated 4 other amino acid substitutions. However, these did not affect M158-66-specific CTL activation.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Proteínas de la Matriz Viral
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Linfocitos T CD8-positivos
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Epítopos de Linfocito T
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Gripe Humana
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Subtipo H1N1 del Virus de la Influenza A
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article