Current Trends in Macrocyclic Drug Discovery and beyond-Ro5.
Prog Med Chem
; 57(1): 113-233, 2018.
Article
en En
| MEDLINE
| ID: mdl-29680148
ABSTRACT
This chapter will discuss the recent literature of macrocycles and drug-like property space moving beyond the rule of five (bRo5). Trends in chemical classes that fall within this definition are discussed and the impact of the latest technologies in the field assessed. The physicochemical properties, which have provided both successes and challenges, especially in scale-up, are discussed. A recent patent literature is reviewed and the chapter concludes with a perspective on the future of macrocyclic drug discovery.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Compuestos Macrocíclicos
/
Descubrimiento de Drogas
Límite:
Humans
Idioma:
En
Año:
2018
Tipo del documento:
Article