Bifunctional Ligand Enables Efficient Gold-Catalyzed Hydroalkenylation of Propargylic Alcohol.
Angew Chem Int Ed Engl
; 57(27): 8250-8254, 2018 07 02.
Article
en En
| MEDLINE
| ID: mdl-29704310
ABSTRACT
Using the previously designed biphenyl-2-ylphosphine ligand, featuring a remote tertiary amino group, the first gold-catalyzed intermolecular hydroalkenylation of alkynes has been developed. Synthetically valuable conjugated dienyl alcohols are formed in moderate to good yields. A range of alkenyltrifluoroborates are allowed as the alkenyl donor, and no erosion of alkene geometry and/or the propargylic configuration are detected. DFT calculations confirm the critical role of the remote basic group in the ligand as a general-base catalyst for promoting this novel gold catalysis with good efficiency.
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Banco de datos:
MEDLINE
Asunto principal:
Propanoles
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Alquinos
/
Oro
Idioma:
En
Año:
2018
Tipo del documento:
Article